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Evaluation of diclofenac in prevention of macular edema following cataract surgery in diabetic patients

Poster Details

First Author: P.Prosio ITALY

Co Author(s):    F. Biondi              

Abstract Details


The purpose of this study was to evaluate diclofenac ophthalmic suspension in the prevention of macular edema following cataract surgery in diabetic patients.


This was a study of 30 adult diabetic patients with nonproliferative diabetic retinopathy requiring cataract surgery.


Patients were randomized (1:1) to instill diclofenac four times daily beginning 1 day prior or after to surgery through day 15. Efficacy included the percentage of patients who developed macular edema (≥30% increase in central subfield macular thickness from baseline) and the percentage of patients with decreases of more than five letters in best-corrected visual acuity from day 7 to 90.


A low percentage of patients developed macular edema (3%). A low percentage of patients had best-corrected visual acuity decreases of more than five letters. The mean central subfield macular thickness and mean percent change from baseline in macular volume were also low.


Diclofenac demonstrated significant and clinically relevant advantages in preventing macular edema and maintaining visual acuity in diabetic patients following cataract surgery. These advantages were seen at multiple time points over the course of the 90-day study period. There was no clinically relevant increase in risk from 14 days dosing. Therefore, the benefit to the diabetic patient undergoing cataract surgery appears to be positive. FINANCIAL INTEREST: NONE

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