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The benefits of steroidal and non-steroidal anti-inflammatory treatment in cystoid macular edema

Poster Details

First Author: S.Badescu ROMANIA

Co Author(s):    C. Tataru   L. Zagrean           

Abstract Details



Purpose:

The purpose of this study was to investigate the clinical outcome of different anti-inflammatory treatments following cataract extraction with posterior chamber intraocular lens implantation and identify the most effective in preventing cystoid macular edema (CME).

Setting:

CME is the most frequent long term complication of cataract surgery. The accumulation of liquid in the macula produces reversible and irreversible changes of the retina, leading to decrease in visual acuity, contrast sensitivity and losing of central visual field. In the treatment and prevention of CME there are different types of non-steroidal anti-inflammatory agents and corticosteroids in topical use; due to the discrepancies between the studies there is no guideline in preventing EMC following cataract surgery.

Methods:

Subjects were randomly assigned to receive either dexamethasone 1% (n=10), indomethacin 0.1% (n=10) or both (n=10) three times daily from day 1 to day 21 postsurgery. All subjects received antiinfective intraoperative and postoperative standard of care. Subjects were followed at 1 week, 1 month and 3 months after surgery. Best-corrected visual acuity (BCVA), contrast-sensitivity, biomicroscopy, intraocular pressure, optical coherence tomography (OCT) were performed at each visit. At OCT retinal thickening and appearance of CME were assessed.

Results:

Following uncomplicated cataract surgery CME was seen in one patient from the indomethacin group. Retinal thickening was significantly higher in the dexamethasone and indomethacin groups compared with the dexamethasone+indomethacine group (p<0.05). While BCVA did not differ, contrast sensitivity was higher in dexamethasone+indomethacine group compared with the other groups.

Conclusions:

This study suggests that using the combination of indomethacin and dexamethasone reduces macular thickening after cataract surgery, improving the visual outcome for patients. FINANCIAL INTEREST: NONE

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