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Comparison of the effect of topical prednisolone 1% versus bromfenac 0.09% versus nepafenac 0.1% versus ketorolac 0.5% on post-operative ocular inflammation and astigmatism following cataract extraction by manual small incision cataract surgery

Poster Details

First Author: N.Pal INDIA

Co Author(s):    S. Thanikachalam   J. Arokiyam   G. Behera   R. Amudhavalli   P. Karunanithy   O. Varshini

Abstract Details



Purpose:

To compare the effect of topical prednisolone1% versus bromfenac0.09% versus nepafenac0.1% versus ketorolac0.5% on post-operative ocular inflammation and astigmatism following cataract extraction by manual small incision cataract surgery.

Setting:

Hospital based Prospective consecutive-assignment randomized clinical trial.

Methods:

Patients undergoing manual small incision cataract surgery were randomly assigned to 4 groups with 50 patients in each to receive topically prednisolone1%, bromfenac0.09%, nepafenac0.1% or ketorolac0.5% postoperatively for 4 weeks. The patients were examined on days 1, 3, 5, 7, 14 and 1 month after surgery. Postoperative inflammation was evaluated subjectively by slit-lamp assessment of cell and flare. Postoperative astigmatism evaluation was done with automated keratometer.

Results:

At each visit there was no statistically significant difference in postoperative inflammation by biomicroscopy for the 4 treatment groups (p=0.285). At first week post-operative evaluation, bromfenac, ketorolac and prednisolone were better at controlling ocular pain as compared to nepafenac (p=0.003), but at 1 month they was no significant difference. There is no significant difference in the postoperative astigmatism between all groups (P=0.204).

Conclusions:

Topical NSAIDs were as effective as topical steroids in controlling post-operative inflammation after manual small incision cataract surgery. FINANCIAL INTEREST: NONE

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