Serum omentin levels in patients with pseudoexfoliation syndrome
First Author: Yasin YucelBucak TURKEY
Co Author(s): Mehmet Tosun Hüseyin Simavlı Mesut Erdurmuş Halil İbrahim Önder
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Omentin, a member of the adipocytokines family, is derived from adipose
tissue and a lower level of serum omentin is considered as a metabolic risk factor. The
aim of the present study is to evaluate the serum levels of omentin in patients with
pseudoexfoliation syndrome (PES).
: Ophthalmology Clinic, Bolu State Hospital; Bolu, Turkey
Patients without any systemic or ocular disease other than PES were
included in the study. Age- and sex-matched healthy volunteers without PES were
accepted as a control group. After detailed ophthalmologic examination, blood samples
were obtained from a forearm vein. Serum levels of omentin were determined by the
method of enzyme-linked immunosorbent assay.
The mean age of the PES group (12 female, 12 male, n=24) was 75.2±8.4
years, and the control group (10 female, 10 male, n=20) was 75±6.7 years. There was
no difference between the groups in terms of age (p=0.93) and sex (p=0.9). The mean
serum levels of omentin in the PES group were 801.5±317.1 ng/ml and in the control
group were 1150.1±584.1 ng/ml. The mean serum omentin levels were significantly
lower in patients with PES (p=0.016).
Lower levels of serum omentin in patients with PES compared to healthy
subjects may support the theory of systemic nature of the disease. FINANCIAL INTEREST: NONE