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Diagnosis of ocular surface squamous neoplasia using high-resolution anterior segment optical coherence tomography: a case series

Poster Details

First Author: NickKopsachilis UK

Co Author(s):    Dipak Parmar   Michael Tsatsos           

Abstract Details


To determine the use of Anterior Segment OCT (AS-OCT) as an optical biopsy method for the diagnosis of OSSN.


: Moorfields Eye Hospital, London, United Kingdom


Ocular surface squamous neoplasia (OSSN) was first described in 1995 as an umbrella term that encompasses intraepithelial and invasive squamous cell carcinoma of the conjunctiva and cornea. It is a slow growing tumor that rarely metastasizes, but is capable of causing extensive local tissue destruction. AS-OCT was performed in four OSSN cases and diagnosis based on Bowman’s infiltration was correlated with the findings of excisional biopsy.


Penetration of Bowman’s membrane correlated with invasive OSSN in all four cases. Treatment included excisional biopsy, MMC and Cryotherapy at the conjuctival wound edges. Histopathological examination of the specimen revealed acanthotic epithelium with squamous metaplasia, occasional dyskeratotic cells, parakeratosis, and hyperkeratosis. Multiple abnormal mitotic figures were present and a diagnosis of conjunctival squamous cell carcinoma in situ was made.


OSSN can be frequently misdiagnosed as pterygium. Correlation between OCT and histopathologic findings confirm that OCT is an adjunctive diagnostic method that can provide a non-invasive method to help guide diagnosis and management of OSSN. FINANCIAL INTEREST: NONE

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