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Multicenter trial on Descemet's membrane endothelial keratoplasty (DMEK): first case series of 18 surgeons

Session Details

Session Title: Cornea

Session Date/Time: Sunday 16/02/2014 | 08:30-11:00

Paper Time: 09:36

Venue: Linhart Hall (Level -2)

First Author: : VasilisLiarakos GREECE

Co Author(s): :    Claire Monnereau   Peter Ciechanowski   Isabel Dapena   Gerrit Melles     

Abstract Details


To document the clinical outcome of standardized ‘no-touch’ Descemet membrane endothelial keratoplasty (DMEK) and its complications during surgeons’ learning curve.


Netherlands Institute for Innovative Ocular Surgery


18 surgeons in 11 different countries performed DMEK for endothelial dysfunction in 431 eyes. Endothelial cell density (ECD), best corrected visual acuity (BCVA) and complications were documented.


94% of the eyes improved their BCVA postoperatively; 79% of them reached a BCVA of ≥20/40, 43% of ≥20/25, and 22% of ≥20/20 within 6 months. Average decrease in ECD was 47% at 6 months. The main postoperative complication was (partial) graft detachment (35%) basically treated with re-bubbling (20%). A re-transplantation was required in 18% of the cases due to primary or secondary failure. Small differentiations in the technique (in terms of the inserter, the storage medium and the air-bubble time) presented a relative effect on the outcome.


Despite the learning curve, DMEK showed feasible and presented favorable outcomes as a new technique. Outsourcing DMEK graft harvesting and adequate choice of preservation medium may enhance the outcome. FINANCIAL INTEREST: NONE