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Clinical aspect and prognosis of candida keratitis in Korea

Session Details

Session Title: Cornea

Session Date/Time: Sunday 16/02/2014 | 08:30-11:00

Paper Time: 09:03

Venue: Linhart Hall (Level -2)

First Author: : Sang-BummLee SOUTH KOREA

Co Author(s): :    Eun-Young Cho   Won mo Gu           

Abstract Details


To investigate predisposing factors, clinical characteristics, treatment results, and prognostic factors in Candida keratitis.


Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea


Fourteen eyes of 14 patients who were diagnosed as Candida keratitis by corneal culture hospitalized at Yeungnam University Hospital (YUH) were included. The past history, symptom duration, visual acuity, location and size of epithelial defect, hypopyon, co-infection, and treatment results were analyzed retrospectively. Treatment success was defined that corneal lesions were successfully healed by only medical treatment.


Previous corneal trauma history, ocular surface disease, and ocular surgery were noticed as frequent predisposing factors. Interval from symptom occurrence to first medical examination at YUH was 23.8 ±20.9 days. The initial visual acuity less than 0.1 were in 11 eyes (78.6%). Four eyes (28.6%) diagnosed as mixed keratitis. The characteristics of the corneal lesions were: a central lesion in 10 eyes (71.4%), the average size of epithelial defect was 11.1 ±12.0 mm2, and hypopyon in 9 eyes (64.3%). Eight eyes (66.7%) underwent surgical treatment: evisceration (5 eyes), conjunctival flap or amniotic membrane transplantation (3 eyes). Treatment success was achieved in 4 eyes (33.3%). Corneal epithelial healing time was 17.5 ±9.6 days. There was significant difference in symptom duration between treatment success and failure groups by univariate analysis (9.3 ±7.4 days vs. 34.5 ±21.9 days, p=0.016).


Candida keratitis usually had a poor prognosis when diagnosed later and in older patients, therefore, early, accurate diagnosis and treatment is important in Candida keratitis care. FINANCIAL INTEREST: NONE