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Evaluation of clarity characteristics in a new hydrophobic acrylic IOL in comparison with commercially available lenses

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Session Details

Session Title: Cataract Surgery Complications: IOL Dislocation and Opacification

Session Date/Time: Tuesday 10/10/2017 | 14:00-16:00

Paper Time: 15:48

Venue: Room 3.6

First Author: : L.Werner USA

Co Author(s): :    I. Thatthamla   M. Ong   K. Das   H. Schatz           

Abstract Details

Purpose:

To perform an in vitro assessment of surface haze, subsurface nanoglistenings (SSNG), as well as glistenings formation of a new hydrophobic acrylic intraocular lens (IOL), and compare it with commercially available hydrophobic acrylic lenses.

Setting:

John A Moran Eye Center, University of Utah, Salt Lake City, Utah, USA, Alcon Laboratories, Inc., Fort Worth, Texas, USA.

Methods:

IOL models used were Alcon Clareon SY60WF, AMO Tecnis ZCB00 and Tecnis OptiBlue ZCB00V, Santen Eternity W-60, B&L enVista MX60, and Hoya Vivinex XY1. Haze was assessed by the pixel intensity (PI) of anterior/posterior surfaces of the IOLs from cross-sectional slit lamp images (BX-900 Haag-Streit). For SSNG assessment, IOLs were subjected to accelerated aging up to 10 yrs. (81 days in BSS at 90°C) followed by Scheimpflug densitometry measurements (EAS-1000 Nidek). For glistening assessment, IOLs were loaded into a 45 °C water bath for 24 hours, then moved into a 37 °C water bath for 2.5 hours prior to analysis.

Results:

Surface haze (N=10, values in PI) was: 4.25 ± 0.87 (SY60WF), 9.50 ± 1.66 (ZCB00), 39.48 ± 1.97 (ZCB00V), 46.68 ± 3.16 (W-60), 44.70 ± 4.00 (MX60), and 4.42 ± 0.71 (XY1), P<0.001 (One Way ANOVA). Densitometry (N=10) after aging was (values in CCT): 7.30 ± 1.36 (SY60WF), 11.88 ± 3.10 (ZCB00), 38.12 ± 2.24 (ZCB00V), 48.13 ± 9.44 (W-60), 20.20 ± 3.84 (MX60), and 6.75 ± 6.66 (XY1), P<0.001 (One Way ANOVA); no difference between SY60WF vs. ZCB00 and XY1. Microvacuole density (N=30) was the lowest for SY60WF and MX60 lenses (0.62 +/- 0.94, and 0.06 +/- 0.31 mV/mm2).

Conclusions:

Nano and micro-sized surface and bulk inhomogeneities of IOLs may be associated with increased light scattering. The new IOL model SY60WF is manufactured from a hydrophobic acrylic material exhibiting very low levels of surface haze, SSNG, and glistening formation.

Financial Disclosure:

is employed by a forNONEprofit company with an interest in the subject of the presentation

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