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Perioperative risk factors for the development of cystoid macular edema after cataract surgery: a report from the ESCRS PREMED Study

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Session Details

Session Title: Cataract Surgery Paediatric/Complications/Management

Session Date/Time: Monday 09/10/2017 | 16:30-18:00

Paper Time: 17:23

Venue: Room 4.1

First Author: : C.Veldhuizen THE NETHERLANDS

Co Author(s): :    L. Wielders   J. Schouten   F. van den Biggelaar   B. Winkens   R. Nuijts        

Abstract Details


To identify and assess perioperative factors influencing the risk of developing cystoid macular edema (CME) after cataract surgery in both diabetic and non-diabetic subjects.


The European Society of Cataract and Refractive Surgeons (ESCRS) PREvention of Macular EDema after cataract surgery (PREMED) study is a European multicenter randomized controlled trial (RCT) investigating the optimal prevention of CME after cataract surgery.


This study investigates possible perioperative risk factors for developing clinically non-significant and clinically significant cystoid macular edema (CSME). Risk factors assessed included the experience of the surgeon (qualified ophthalmologist vs. trainee status), whether or not femtosecond laser-assisted cataract surgery (FLACS) was performed, and whether a hydrophobic or hydrophilic intraocular lens (IOL) was implanted. Logistic regression with correction for preventative strategy was separately applied to each potential perioperative risk factor. A Fisher’s exact test was used for diabetic subjects due to small number of subjects who developed CME.


Preliminary results suggest that for both diabetic and non-diabetic subjects, surgeon experience, FLACS, and IOL material are not statistically significant risk factors for developing CME and CSME at 6 weeks after cataract surgery. Similar conclusions were obtained after correcting for PREMED preventative treatment interventions.


Based on preliminary results of the ESCRS PREMED study, we found no statistically significant perioperative risk factors for CME and CSME at 6 weeks after cataract surgery in both diabetic and non-diabetic subjects.

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