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Customized patient care: first clinical outcomes with a novel monofocal intraocular lens for individual spherical aberration correction

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Session Details

Session Title: Pseudophakic IOLs: Multifocal I

Session Date/Time: Sunday 08/10/2017 | 08:00-10:00

Paper Time: 08:18

Venue: Room 2.1

First Author: : T.Neuhann GERMANY

Co Author(s): :    J. Schrecker                    

Abstract Details


To evaluate the efficacy of a single-piece hydrophilic acrylic monofocal aspheric intraocular lens (IOL) which allows individual correction of corneal spherical aberration (SA) of a specific eye.


MVZ Prof. Neuhann, Munich, Germany; Augenklinik Rudolf Virchow Klinikum, Glauchau, Germany


In an ongoing prospective multicenter study cataract patients were randomized to receive either an aspheric individual aberration-correcting IOL (INVIDUA-aA, HumanOptics AG, Germany) or an aspheric aberration-neutral IOL of the otherwise identical lens design (ASPIRA-aA, HumanOptics AG).In the custom group, IOL asphericity was designed according to preoperative total corneal SA Z(4,0) measurements in order to achieve an overall ocular SA close to zero µm. Four weeks, 3 months and 1 year postoperatively, monocular uncorrected and corrected distance visual acuity (UDVA, CDVA), photopic and mesopic contrast sensitivity with and without glare, ocular aberrometry and defocus curve were measured.


So far, 56 eyes in the custom group and 34 eyes in the control group completed the 4-week follow-up examination. Preoperative total corneal SA showed no difference between groups (p=.456). Postoperatively, residual ocular SA Z(4,0) measurements showed significant lower values (close to zero µm) in the custom group at 2-,3-,4- and 5-mm scan sizes (p<.05). Custom IOLs provided better monocular UDVA and CDVA. Results of monocular defocus curves tend to be better in the custom group. Photopic and mesopic contrast sensitivity with and without glare was significantly higher in custom IOL-implanted eyes at almost all spatial frequencies (p<.05).


Pre-surgical corneal SA measurement followed by implantation of the new INVIDUA-aA IOL that matches the individual corneal asphericity was safe and effective in reducing the overall ocular SA to a minimum. Preliminary clinical outcomes indicate that lenses with individual modification of asphericity can improve functional vision compared to an aberration-neutral IOL.

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