Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Comparison of three different hyperopic treatment options

Poster Details

First Author: J. Mehta SINGAPORE

Co Author(s):                        

Abstract Details


Laser Assisted In Situ Keratomileusis (LASIK) is a well-established technique for correcting hyperopia, but regression of refractive power is a common issue post-operation. In hyperopic SMILE, the femtosecond laser dissects out a concave lenticule, which is extracted from the cornea, achieving a steeper central corneal configuration with higher refractive power. Implanting a convex lenticule, which in turn is derived from femtosecond laser-guided lenticule extraction, is yet another option to address hyperopia.


Singapore Eye Research Institute


18 macaques were divided into six groups of three. In two groups, +2.0D hyperopic treatments were performed, with LASIK on one eye, and SMILE on the other eye. This was repeated in another two groups, but with +4.0D treatment. In the fifth group, a -2.0D lenticule was extracted from one eye of each monkey and implanted autologously into the other eye; this procedure was performed again with -4.0D lenticules in the sixth group. Slit-lamp imaging, anterior segment OCT, in-vivo confocal microscopy, keratometry and refractive error measurements were performed pre-operatively and post-operatively. Immunohistochemistry was done at 3 months.


Slit-lamp examination showed clear corneas throughout follow-up in all groups. Refractive parameters including corneal thickness, anterior curvature and refractive error indices were not statistically different amongst treatment modalities. In-vivo confocal microscopy showed similar patterns across all groups over time. Immunohistochemistry showed comparable inflammatory responses, and no structural deficits with different treatments.


The results from our study suggests that SMILE and lenticule re-implantation are safe and viable methods for treating hyperopia. SMILE may be comparable to LASIK for both +2.0D and +4.0D treatments; re-implantation may be comparable to LASIK for +4.0D treatment, but was not effective in +2.0D treatment.

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