Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Biomarkers for diagnosis of glaucoma in Korea

Poster Details

First Author: K. Yi KOREA, SOUTH

Co Author(s):    E. Kim   Y. Shin   K. Han              

Abstract Details


To evaluate the biomarkers for diagnosis of glaucoma in Korea and racial differences between the present and previous studies


cross sectional study


Volunteers with/without glaucoma were enrolled between January and October 2015. The analyzed biomarkers included anti-Sjögren's-syndrome-related antigen A (SSA), anti-Sjögren's-syndrome-related antigen B (SSB), heat shock protein 60 (HSP60), anti-myelin basic protein (MBP), anti-alpha-fodrin and anti-nucleic acid (ANA). Qualitative and quantitative analyses were performed on these samples.


Among the 42 volunteers, three were excluded owing to blood-sample hemolysis. The remaining 39 patients were divided into their respective groups: glaucoma (22) and normal (17). The glaucoma group included two types of glaucoma: normal-tension glaucoma (NTG: 14 patients) and primary angle-open glaucoma (POAG: 8 patients). The serum ELISA titers of the antibodies against MBP were higher in the glaucoma than in the normal controls. And the levels of antibodies against SSA, SSB and alpha-fodrin significantly differed between the NTG and POAG groups.


These findings suggest that biomarker patterns can differ between normal, NTG and POAG groups. Certainly, autoimmunity has a potential role in the development and progression of glaucoma, and its mechanisms in the forms of biomarkers can be utilized as effective glaucoma-diagnostic tools.

Financial Disclosure:


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