Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Clinical features, antibiotic susceptibility profile, and outcomes of infectious keratitis caused by stenotrophomonas maltophilia

Poster Details

First Author: S. Palioura UNITED STATES

Co Author(s):    A. Gibbons   D. Miller   T. O'Brien   E. Alfonso   O. Spierer        

Abstract Details


To develop a better understanding of the clinical features, antibiotic susceptibility profile, and treatment outcomes of infectious keratitis caused by Stenotrophomonas maltophilia. Though uncommon, this aerobic gram-negative bacillus is particularly difficult to treat due to its resistance to multiple antibiotics.


The Bascom Palmer Eye Institute at the University of Miami Miller School of Medicine, a tertiary ophthalmology referral center in South Florida, USA.


A retrospective review of records from November 1989 to February 2014 identified 22 eyes of 22 patients who were treated at the Bascom Palmer Eye Institute for a corneal ulcer caused by S. maltophilia. Clinical data was analyzed as to predisposing factors, vision at presentation and after treatment, clinical presentation, antibiotic susceptibility, treatment selection and clinical outcomes.


Mean age at presentation was 66.2 ± 20.2 years. Nine patients (40.9%) were contact lens wearers and 5 (22.7%) had a history of penetrating keratoplasty. Vision at presentation ranged from 20/25 to no light perception. All patients received topical antibiotics, one required a therapeutic penetrating keratoplasty and one was enucleated. Final best-corrected vision ranged from 20/20 to no light perception. Nine patients (40.9%) had visual acuity 20/100 or worse at final visit. Nineteen of the 22 strain isolates (86.3%) were resistant to tobramycin and 18 (81.8%) to ceftazidime. Almost all isolates (20/22, 90.9%) were susceptible to the fluoroquinolones and to polymyxin/trimethoprim.


This is the largest series of corneal ulcers due to the opportunistic pathogen S.maltophilia. Infectious keratitis due to S. maltophilia presents a treatment challenge due to its resistance to aminoglycosides and cephalosporins, which are typically used for empiric broad spectrum gram negative coverage as fortified solutions. Fluoroquinolones and polymyxin/trimethoprim should be used instead in cases of S. maltophilia infection.

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