Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Corneal stroma demarcation line after four different protocols of corneal collagen cross-linking in keratoconus determined with anterior segment optical coherence tomography

Poster Details

First Author: L. Spadea ITALY

Co Author(s):    E. Tonti   L. Di Genova                 

Abstract Details


To use anterior segment optical coherence tomography (AS-OCT) to compare corneal stroma demarcation line depth after corneal collagen crosslinking (CXL) with 4 treatment protocols.



Eye Clinic, “A. Fiorini” Hospital, Sapienza University of Rome, Terracina (Latina), Italy.


Corneal collagen cross-linking was performed as following: 1) conventional 3 mW/cm2 according to the standard Dresden protocol (C-CXL), 2) accelerated 10 mW/cm2 (A-CXL), 3) transepithelial 3 mW/cm2 (TE-CXL) and 4) transepithelial by iontophoresis 10 mW/cm2 (I-CXL). A total of 120 eyes of 70 patients with progressive keratoconus who was divided into four groups: C-CXL (n = 30), A-CXL (n = 30), TE-CXL (n = 30), and I-CXL (n = 30). Two independent observers measured the corneal stroma demarcation line using AS-OCT.


Corneal stromal demarcation line was identified on AS-OCT scans in all eyes by both observers. The mean depth of stromal demarcation line was 275.70 ± 41.83 μm in C-CXL group, 279.35 ± 33.07 μm in A-CXL group, 132.60 ± 22.14 μm in TE-CXL group and 235.4 ± 37.08 μm in I-CXL group. The difference in stromal demarcation line depth was not statistically significant between C-CXL and A-CXL group, but it was statistically significant between the first 2 groups and TE-CXL and I-CXL group (p <.001).


The corneal stroma demarcation line was significantly deeper after a 30-minute standard CXL treatment and after accelerated CXL procedure with high-intensity UVA irradiation, and significantly shallower after transepithelial corneal cross linking.

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