Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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A longitudinal study of the tear film function after corneal cross-linking in keratoconus

Poster Details

First Author: J. Recalde SPAIN

Co Author(s):    I. Rodriguez Agirretxe   M. Sanchez Tena   A. Acera Osa   J. Duran           

Abstract Details


To analyse the variations in tear quantity and quality after corneal cross-linking (CXL) in patients with keratoconus


Clinico-Quirurgico de Oftalmología. Bilbao, Basque Country. Spain.


24 patients with keratoconus underwent epi-off CXL. Studied variables were tear film osmolarity (OSM), subjective symptoms (OSDI Index), Tear Break-Up Time (TBUT), Schirmer´s Test (SCH), Tear Clearance (TCL), Lacrimal Function Index (LFI), Oxford Staining Score (OXF) and Van Bijsterveld Lissamine Green Staining (LGS). Variables were determined preoperatively and 3, 6 and 12 months after CXL.


All the studied variables remained stable after one year´s follow-up (NSD related to the basal situation; Mann-Whitney´s U test). There was a positive paired correlation between SCH and TCL at 3 (p<0.01), 6 (p=0.04) and 12 months (p<0.01), SCH and LFI at 3 (p<0.01), 6 (p=0.01) and 12 months (p=0.01), and between TCL and LFI at 3 (p<0.01) and 12 months (p=0.02). There was no correlation between SCH and BUT. A negative correlation was found between OSM and SCH at 3 (p<0.01) and 12 months (p=0.04). OSDI did not correlate with any of the studied variables (Spearman test).


Cross-linking, at least during the first postoperative year, doesn´t modify the parameters currently used to evaluate the tear film function. There is a gap between objective and subjective parameters of tear film function analysis.

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