Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Accelerated collagen cross-linking of cornea (CXL) with isotonic riboflavin solution in progressive keratoconus in North Indian population: short-term results

Poster Details

First Author: A. Mazhari INDIA

Co Author(s):    R. Shukla   P. Chakarpani   P. Mahajan   R. Kairati           

Abstract Details


To evaluate the refractive and clinical outcomes of 10 minutes protocol of accelerated corneal collagen cross-linking (CXL) with the help of topography, pachymetry and high definition OCT after collagen cross-linking in eyes with progressive keratoconus in north Indian population.


Cornea and refractive surgery services, Indira Gandhi Eye Hospital and Research Centre, Lucknow, India


54 eyes underwent epithelium off accelerated collagen cross-linking by instilling isotonic riboflavin 0.1% solution containing 20% dextran every 3 minutes for 30 minutes before, and during the 10 minutes of ultraviolet A irradiation (9 mW/cm2) by Lightmed-Lightlink crosslinking system. We measured the UDVA, CDVA, refraction, topographic values (Atlas 9000 topographer, Carl Zeiss), pachymetry values (Visante ASOCT, Carl Zeiss) and demarcation lines (HDOCT, Carl Zeiss ) at 1 week and at 1, 3, and 6 months after surgery and these were compared with preoperative findings.


Mean UDVA and CDVA (in decimal) were 0.18±0.18 and 0.53±0.21 preoperatively which progressively improved to 0.23±0.19 and 0.54±0.22 respectively at 6 months. Preoperatively mean spherical refraction was -3.30±3.11 DS and cylindrical refraction was -3.19±2.23 DC which improved to -2.97±3.12 DS and - 2.61±1.94 DC respectively. Mean Kmax preoperatively was 50.54±4.27 D which changed to 48.03±5.14 D at 6 months. Mean minimum corneal thickness (MCT) preoperatively was 449.50±45.43 μm and it was 432.20±49.48 μm at 6 months. Mean demarcation line one week postoperatively was 290±14.24 μm which got stabilized to 259.67±23.11 μm at 6 months.


Ectasia due to keratoconus was arrested by accelerated CXL in our cases with stabilization or improvement of mean UDVA, CDVA, refraction and Kmax after 6 months of follow-up. There were improvements in topography indices, suggesting a more regular corneal surface. We also studied the effect of CXL on corneal stroma by analysing the demarcation lines during the follow-ups.

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