Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Analysis of corneal densitometry 3 months after accelerated corneal collagen cross-linking

Poster Details

First Author: M. Böhm GERMANY

Co Author(s):    M. Remy   M. Shajari   T. Kohnen              

Abstract Details


To analyse changes in corneal densitometry 3 months after accerlerated corneal collagen crosslinking (CXL) in patients suffering from progressive keratoconus, pellucid marginal degeneration (PMD) or iatrogenic ectasia (IE) after corneal refractive surgery.


Department of Ophthalmology, University of Frankfurt, Germany


This study retrospectively reviewed charts and anterior segment data of patients who had undergone accelerated pulsed (1 second “on”, 1 second “off”) epithelium-off CXL (0.1% VibeX RapidTM Riboflavine; 30 mW/cm2 for 4 minutes; 7.2 J/cm2; 8 minutes total radiation time) for treatment of progressive keratoconus, PMD or IE after corneal refractive surgery. Visual acuity, clinical, topographic, pachymetric and densitometric data were extracted from charts, Scheimpflug-tomography (Pentacam HR, Oculus) and Optical Coherence Tomography (VisanteTM OCT, Zeiss). Data from before surgery and at follow-up 3 months after treatment was statistically analyzed.


The study evaluated 20 eyes of 20 patients. The mean densitometry of different stromal corneal layers (anterior, middle, posterior) and in four zones (0-2 mm, 2-6 mm, 6-10 mm, 10-12 mm) of the entire cornea depth increased compared to baseline. The anterior (120 μm) stromal layer within the 0-2 mm zone showed a significant elevation after three month (p< 0.006). A mean stromal demarcation line was apparent at a depth of 203.00 μm +/-12.51 (SD). There was no change in mean best corrected distance visual acuity, however, a decrease in pachymetry (μm) was found after three months.


Accelerated CXL results in an increase in densitometry, particularly in the anterior stromal layer of the cornea within the 0-2 mm zone compared to baseline at three months postoperatively. Further research, including a longer follow up time, is needed to verify these findings.

Financial Disclosure:

One or more of the authors travel has been funded, fully or partially, by a competing company

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