Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Results of new pulsed high fluence protocol for corneal collagen cross-linking in keratoconus

Poster Details

First Author: F. Allen UNITED KINGDOM

Co Author(s):    O. Bowes   V. Barnett   A. Barsam              

Abstract Details


Progression of keratoconus has been prevented by corneal cross-linking involving the use of riboflavin and ultraviolet A (UV-A) irradiation. The standard Dresden protocol involves a 30 minute riboflavin soak and 30 minute UV-A exposure (3mW/cm2). We present the results using a pulsed and high fluence protocol in patients with progressive keratoconus to arrest progression of disease whilst reducing treatment time.


Outpatient tertiary cornea service within a National Health Service hospital in England.


Twenty consecutive eyes (n=20) of patients with documented high risk progressive keratoconus received the new protocol of riboflavin soak for 10minutes, followed by UV-A administration over 6.40 minutes, pulsed for 10 minutes in total at 18mW/cm2 (2 seconds on, 1 second off). The visual acuity and pentacam results were evaluated at 6 (n=20) and 12 (n=10) months postoperatively.


At 12 month postoperative there was a mean corneal flattening of 1.4 diopters (Kmax) and a mean improvement in visual acuity of 0.17 (LogMAR) compared to preoperatively. There were no complications.


Our results show that reducing UV exposure and soak time as per a high fluence and pulsed protocol allows for a quicker treatment without compromising accepted efficacy and safety profiles

Financial Disclosure:


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