Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Phototherapeutic keratectomy in eyes with persistent macro-epithelial defects following penetrating keratoplasty

Poster Details

First Author: D. Maltsev RUSSIAN FEDERATION

Co Author(s):    S. Churashov   V. Chernysh   E. Kudryashova              

Abstract Details


Phototherapeutic keratectomy (PTK) is an important treatment for eyes with recurrent corneal erosion syndrome. Reported success rates for this treatment in recurrent corneal erosion varies from 69% to 86%. Persistent macro-epithelial defects following penetraiting keratoplasty may predispose the graft to infectious keratitis and secondary failure. As there are no reports of PTK efficacy for persistent macro-epithelial defects following penetraiting keratoplasty, the objective of this study was to present the outcomes of donor graft persistent macro-epithelial defects treated by “wet” PTK.


Department of Ophthalmology Military Medical Academy, St. Petersburg, Russia.


This study included patients who had macro-epithelial defects of the donor graft lasting more than 3 months and had failed previous treatment modalities. All procedures were performed using the EC-5000 excimer laser. The “wet” PTK was performed by first flooding the erosion zone with balanced salt solution (acting as a masking agent) followed by a 60-µm ablation. The second step of PTK treatment was performed over the dried graft surface with an ablation depth up to 30 µm. After the procedure a soft contact lens was placed and fixed combination of glucocorticoid and antibiotic was prescribed for 2 weeks.


Six eyes of 6 patients (3 man and 3 women; mean age 57.3 ± 10.2 years) were treated for persistent macro-epithelial defects of the donor graft with “wet” PTK. Before PTK all patients had failed extended wear of soft contact lenses, amniotic membrane transplantation (1 to 3 procedures) and temporary tarsorrhaphy (2 cases). The mean corrected distant visual acuity was 1.79 ± 0.24 logMAR preoperatively and improved significantly to 1.04 ± 0.21 logMAR 10 days postoperatively (p = 0.027), remains stable during mean follow-up of 5.8 ± 1.6 months. There were no any postoperative complications or recurrence of macro-epithelial defects during follow-up period.


“Wet” phototherapeutic keratectomy appears to be successful for patients with macro-epithelial defects of the donor graft following penetraiting keratoplasty who have failed conservative measures or previous surgical interventions.

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