Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Clinical characterization of corneal features in Down's syndrome patients

Poster Details

First Author: A. Vega-Estrada SPAIN

Co Author(s):    A. Osman   P. Sanz Di­ez   A. Kamal   J. Alio           

Abstract Details


To characterize the main features of the cornea in patients with Down syndrome.


Vissum, Alicante, Spain. Division of Ophthalmology, Miguel Hernández University, Alicante, Spain. Faculty of medicine, Cairo University, Egypt. Pediatric hospital, Genetic clinic, Egypt.


Prospective and multicentric study we included a total of 217 eyes of 110 patients with ages ranging from 60 to 1 year (mean age of 23.3 ± 13.8 years). All cases were divided into two groups according to the level of cooperation that had patients during eye examination. The cooperative group consisted in cases that underwent a full ocular examination, refraction, fundoscopic exam, topography, aberrometry examination and axial length measurement. The uncooperative group consisted in cases that who had a full ocular examination, refraction, fundoscopic exam but they were totally uncooperative to perform topography and aberrometry or axial length measurements.


123 cases from cooperative group and 94 cases from uncooperative group. 55 patients (50%) were men and two 55 patients (50%) women. The mean refractive spherical equivalent was -2.28±6.21 diopters. Mean keratometric values were 46.32±6.14 diopters in flat meridian and 49.63±8.05 diopters in steep meridian. Mean asphericity in a 4.5 mm diameter corneal area was -0.55±1.12, and mean asphericity in an 8.0 mm was -0.70±1.33. The axial length values were 24.97±1.98 mmHg. The intraocular pressure values were 14.64±3.20 mmHg. Analysis of coma-like corneal aberrometry showed 1.85±4.37 µm. In biomechanical data we observed CH = 9.95±0.91 and CRF = 8.75±1.62 mmHg.


BThe effect that the presence of this genetic alteration causes in each person varies widely. In these cases a high prevalence of corneal disorders were found. The study a corneal features of Down syndrome patients is very important to have a greater knowledge of the behavior of corneal collagen in these patients.

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