Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Comparison of the tear osmolarity levels between glaucoma patients under IOP lowering medication and healthy controls

Poster Details

First Author: J. Paz Moreno-Arrones SPAIN

Co Author(s):    M. Castejon Cervero   D. Ferrari   M. Roldan Diaz   M. Teus           

Abstract Details


The purpose of this study was to evaluate, using different cutoff levels, the prevalence of tear film hyperosmolarity in patients suffering from glaucoma and chronically treated with topical IOP-lowering eyedrops and compare it with healthy controls.


Service of Ophthalmology, University Hospital Principe De Asturias


This is a cross-sectional, observational study. We recruited healthy non-glaucomatous age-matched patients (controls) with glaucoma patients under chronic treatment with topical antiglaucomatous eyedrops. Tear film osmolarity was measured with the TearLab® Osmolarity System (TearLab Corp, San Diego, CA), and the results were compared between both groups, using different cutoff levels (308, 312 and 316 mOsm/L). Patients with prior ocular surgery in the previous 12 months were excluded.


74 patients were enrolled, 24 in the glaucoma group and 50 in control group. Mean age was 66.7±11.2 vs 70.8±7.7 years respectively (p>0.05). A significantly higher mean tear film osmolarity was observed in glaucoma group: 318,16±13,05 vs 305,44±15,37 mOsm/L in glaucoma and control groups, respectively (p=0.007). Using 308 mOsm/L cutoff level, 23 patients (46%) in control group had hyperosmolar tears versus 19 patients (79%) in glaucoma group (p=0,0001). Using 312 mOsm/L cutoff level, 14 patients (28%) were classified as hyperosmolars in the control group versus 16 patients (66,6%) in glaucoma group (p=0,0001). Finally, using 316 mOsm/L cutoff level, 8 patients (16%) in the control group had hyperosmolar tears versus 14 patients (58,3%) in glaucoma group (p=0,0002).


Patients chronically treated with IOP-lowering medications exhibit tear film hyperosmolarity in comparison with a healthy control group.

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