Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Therapeutic effect of amniotic membrane transplantation in paraquat-induced ocular surface injury: case reports

Poster Details

First Author: P. Lee TAIWAN

Co Author(s):                        

Abstract Details


Paraguat is an herbicide with dipyridylium quaternary ammonium salt as main content. It is extremely toxic to humans and may produce multiple organ failure. In contrast to systemic toxicity, treatment and prognosis of ocular surface toxicity are not well described. We report 2 patients with paraquat induced ocular surface injury, one treated successfully with medical treatment and the other received amniotic membrane transplantation and with well healed epithelium.


It’s a retrospective case report.


Clinical appearance and progress of bilateral ocular chemical injury caused by paraquat were recorded. One patients received amniotic membrane transplantation surgery and clinical results were analyzed


After a short course (5~7days) of medical treatment. One patient’s cornea and conjunctiva healed spontaneously(Figure 1, Case 1) but the other patient (figure 2, Case 2) had poor healing epithelial defect. Therefore, amniotic membrane (AM) grafting operation was arranged and covered to the ocular surface of lesion eye and sutured to the conjunctiva with 10-0 nylon. During this procedure, partial limbal conjunctiva tissue was excised for pathological report, and showed severe lymphocytic infiltration and disc ernible fibrosis. After operation, the conjunctival erosion started healing and pseudomambrane formation decreased. Corneal epithelial defect healed completely after removing AM graft, and without the development of conjunctivalization of the cornea


Paraquat-induced ocular surface injury had a relatively good prognosis. Amniotic membrane has antiantiangiogenic, antiscarring, and anti-inflammatory properties. In our cases, it could be used as a graft for corneal and conjunctival reconstruction, and facilitate epithelialization and suppress inflammation in acute stage of chemical injury.

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