Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Tear osmolarity in ocular graft versus host disease

Poster Details

First Author: M. Cabanas SPAIN

Co Author(s):    A. Munoz-Morales   M. Caro-Magdaleno   J. Del Trigo Zamora   J. Sanchez Vicente   A. Alfaro Juarez   J. Montero     

Abstract Details


To asses the elevation of tear osmolarity in chronic ocular Graft Versus Host Disease


Chronic ocular GVHD occurs in 40-60% patients with hematopoietic transplant. DES in the more frecuent complication. It is important to make a promnt diagnosis. Tear osmolarity can be a usefull tool for this patients.


16 eyes of 8 patients affected by ocular cGVHD were evaluated with TearLab Osmolarity System (TearLab Corp, San Diego,CA). It was the first test done in the patient, between 9-10 am,without artificial teardrops at least 8 hours before examination. We measure osmolarity in 16 eyes of 8 healthy patients. Differences between both groups was made by statistical analysys using SPSS.


The mean +/- SD of tear osmolarity measure in the GVHD group was 312 +/- 4 mOsm/L and in the control group was 298 +/- 5 mOsm/L. Tear osmolarity significantly increases with severity of DES in GVHD. It was significantly higher in the GVHD group compaired with the control group.


The results are in accordance with literature. Tear osmolarity can be a usefull tool to help in diagnose ocular GVHD from healthy eye. A test value higher from 308 mOsm/L is significantly correlate with DES in ocular GVHD.

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