Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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DNA positive heterozygous GCD-1 diagnosed after PRK

Poster Details

First Author: M. Balidis GREECE

Co Author(s):    N. Dragoumis   D. Mikropoulos                 

Abstract Details


To present a previously undiagnosed familial case of stromal dystrophy (Granular Corneal Dystrophy Type I or GCD-1) detected postoperatively on a corneal graft.


“Ophthalmica” private Eye Institute, Thessaloniki, Greece.


A 38-year-old patient presented following a bilateral penetrating keratoplasty, with unclear ophthalmic history. Refractive correction and topographic data demonstrated high postoperative astigmatism in both eyes. The patient underwent PRK with mitomycin C bilaterally. 9 months post PRK, there were multiple bilateral whitish stellate and linear corneal opacities. AS-OCT revealed hyperreflective deposits within the anterior stroma in both eyes. After obtaining a family history, a first and second degree relative with an unknown eye condition were identified. They were subsequently examined and found to have a similar phenotype. DNA testing was positive in all three patients for heterozygous GCD-1.


A diagnosis of GCD-1 was established which in the initial patient manifested on the corneal graft after PRK was performed for high postoperative astigmatism.


It is evident that PRK is responsible for accelerating the manifestation of GCD-1 or GCD-2. This is the first reported case of DNA positive heterozygous GCD-1, presented in three family members in Southeastern Europe.

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