Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Intraoperative floppy iris syndrome: tamsulosin versus doxazosin

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Session Details

Session Title: Presented Poster Session: Solutions for Traumatic Cases

Session Date/Time: Tuesday 13/09/2016 | 09:30-11:00

Paper Time: 10:20

Venue: Poster Village: Pod 3

First Author: : S.Masnec CROATIA

Co Author(s): :    M. Kalauz   T. Kuzman   R. Kordić   I. Å kegro   S. Jandroković   T. Jukić

Abstract Details


to compare the incidence and severity of intraoperative floppy iris syndrome (IFIS) in patients taking tamsulosin or doxazosin


University Hospital Center Zagreb, Department of Ophthalmology, Zagreb, Croatia


Prospective study included 1892 patients on systemic tamsulosin or doxazosin therapy over a 2 years period of recruitment (November 2013- November 2015). Phacoemulsification with intraocular lens implantation was performed, by the same surgeon, without using phenylephine or epinephrine. The surgical procedure was recorded and videotaped. The presence of IFIS was evaluated and graded. Grading was performed as follows: 1: none or presence of iris fluttering only; 2: iris fluttering with pupil constriction ≥ 2 mm or iris prolapse; 3: iris fluttering, pupil constriction ≥ 2 mm and iris prolapse. For statistical analysis chi square test was used


A total of 1892 patients were enrolled. IFIS was noted in 53 patients (2.8%) taking tamsulosin and in 15 patients (0.8%) taking doxazosin. In tamsulosin group, 20.75% of patients had symptoms of mild IFIS (grade 1), 47.17% moderate (grade 2) and 32.08% severe IFIS (grade 3). 20% of doxazosin group showed symptoms of mild, 60 % of moderate and 20% of severe IFIS. There was no statistically significant difference between the two groups (X²=0,48; P=0,616). Also no significant difference between the groups analyzing moderate + severe IFIS was noted (X²=0,96; P=0,327). There were no significant surgical complications in either groups.


When phenylephine or epinephrine are omitted intraoperatively as a prophylaxis, moderate to severe IFIS can occur. Although both tamsulosin and doxazosin significantly increase the risk of intraoperative floopy iris syndrome,our data indicate that there is no statistically significant difference between them regarding the severity of iris fluttering, pupil constriction and iris prolapse.

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