Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance
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10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits

 

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Efficacy and optical quality of topical 3.0% diquafosol, 0.05% cyclosporine A and 0.1% sodium hyaluronate in dry eyes after cataract surgery

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Session Details

Session Title: Presented Poster Session: Dry Eye

Session Date/Time: Tuesday 13/09/2016 | 09:30-11:00

Paper Time: 10:00

Venue: Poster Village: Pod 1

First Author: : J.Lee SOUTH KOREA

Co Author(s): :    S. Yun              

Abstract Details

Purpose:

To evaluate the efficacy and optical quality of topical 3.0% diquafosol, 0.05% cyclosporine A and 0.1% sodium hyaluronate in dry eyes after cataract surgery.

Setting:

Kangdong Sacred Heart Hospital, Hallym University, Seoul, Republic of Korea

Methods:

Sixty-two newly diagnosed patients (75 eyes) with dry eye syndrome 1 week after cataract surgery were randomized to receive either topical 3% diquafosol ophthalmic solution (n=25) 6 times daily, 0.05% cyclosporine A (n=25) 2 times daily or 0.1% sodium hyaluronate (n=25) 4 times daily. The tear film break up time (T-BUT), Schirmer test l (ST-l), corneal fluorescein staining score, higher-order aberrations (HOA) and ocular surface disease index (OSDI) score were examined at 1, 2 and 3 months.

Results:

There were significant differences (p<0.05) in T-BUT (1,2,3 months), Schirmer test l (1 month), corneal fluorescein staining score (3 months), total HOAs (3 months) and vertical coma (2,3 months) among the three groups. 3.0% diquafosol showed greater efficacy in T-BUT (p<0.001) and corneal fluorescein staining (p =0.001) than 0.1% sodium hyaluronate, and 0.05% cyclosporine A revealed superior effectiveness in vertical coma (all, p<0.05) than 3.0% diquafosol (2,3 months). 0.1% sodium hyaluronate group had a tendency to improve all ocular measures, but showed insufficient efficacy compared with the other groups.

Conclusions:

Topical 3% diquafosol, 0.05% cyclosporine A, and 0.1% sodium hyaluronate showed improvement in dry eye after cataract surgery. However, 3% diquafosol revealed best improvement in T-BUT and corneal fluorescein staining, and 0.05% cyclosporine A showed greatest efficacy in improving higher order aberrations.

Financial Disclosure:

NONE

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