Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance
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10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits

 

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Comparison of ganciclovir concentration in aqueous humor after topical administration: a pilot study

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Session Details

Session Title: Presented Poster Session: Endophthalmitis/Ocular Infections

Session Date/Time: Monday 12/09/2016 | 15:00-16:30

Paper Time: 15:10

Venue: Poster Village: Pod 3

First Author: : P.Choopong THAILAND

Co Author(s): :    P. Choopong   N. Tesavibul   V. Laksanaphuk   B. Hunchansith   W. Chandranipapongse   P. Jutasompakorn

Abstract Details

Purpose:

To compare concentration of 2% ganciclovir eye drop versus 0.15% ganciclovir eye gel in aqueous humor at 30 minutes, 1 hour, 2 hours, and 3 hours after topical administration

Setting:

Siriraj hospital, Mahidol University

Methods:

Healthy volunteer undergoing phacoemulsification or extracapsular cataract extraction was randomly applied with 2% ganciclovir eye drop or 0.15% ganciclovir eye gel 30 minutes, 1 hour, 2 hours, and 3 hours before the operation. Aqueous humor was aspirated at the beginning of cataract surgery. Mass spectrometry was performed to determine the concentration of ganciclovir in aqueous humor.

Results:

Forty patients were included. Twenty of them were randomly received 2% ganciclovir eye drop while the others got 0.15% ganciclovir eye gel. Mean aqueous humor volume, the concentration of ganciclovir, and drug half-life were determined.

Conclusions:

Aqueous humor concentration of 2% ganciclovir eye drop may be comparable with 0.15% ganciclovir eye gel at specific time points. This may be useful in the treatment of intraocular herpes virus infection.

Financial Disclosure:

NONE

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