Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Implantation of corneal inlays for presbyopia correction in an experimental study in vivo

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Session Details

Session Title: Presented Poster Session: Refractive Corneal Inlays

Session Date/Time: Monday 12/09/2016 | 15:00-16:30

Paper Time: 16:00

Venue: Poster Village: Pod 2

First Author: : Y.Shkandina RUSSIA

Co Author(s): :    I. Mushkova              

Abstract Details


To examine in an experimental study in vivo the impact of the developed corneal inlays, made of polymer materials based on hydroxyethylmethacrylate (HEMA) and olygourethanmethacrylate (OUMA), on the structure of the anterior segment of rabbit eyes.


S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation


Material for the study were 3 groups of chinchilla rabbits breed. Basic group 1 of experimental animals-6 rabbits (6 eyes) were implanted corneal inlays made of HEMA. Basic group 2 -6 rabbits (6 eyes) were implanted inlays made of OUMA. Group 3 -control-used the second eye (12 eyes) of experimental animals from groups 1 and 2, without implantation of lens.We carry out mechanical delamination of middle layers of the stroma by straight knife forming a corneal pocket with subsequent implantation of inlay.We used standard methods (biomicroscopy of the anterior segment, ophthalmoscopy) and special ophthalmic metods (optical coherence tomography OCT).


In 5 of 6 animals in basic groups cornea around lens was transparent, without defects of the stroma and epithelium under the lens during 2 month.Cases of vascularization, inflammatory reactions or visible changes in the fundus in all groups were not found.Group 1-1 case of ulcer formation under the lens followed by a protrusion in the conjunctival cavity.Group 2-1 case of decentration of inlay.OCT images showed in all groups an increase in corneal thickness.In control group this index returned to the preoperative value 1 month later.In basic groups maintained the increase in thickness 2 months later,in group 1-on average by 28.6 μm,in group 2 - 27.1 µm. The depth of corneal pocket in all groups was 171-181 µm.


Based on modeling of postoperative period after the implantation of corneal inlays revealed that the developed lenses did not cause severe inflammatory reactions of rabbit eyes, had a stable position in the corneal pocket. After the implantation the corneal thickness increased by 28.6 ± 2.41  μm in the group using HEMA and by 27.1±3,97  μm using OUMA. However, when the thickness of implantation less than 150  μm, perhaps the formation of ulcer under inlay, followed by lens protrusion to the 2nd month after surgery. In group 2 with incomplete adhesion in interface is possible decentration of inlay

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