Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance
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10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits

 

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Corneal grafts confocal scan study and biomechanical properties following Descemet-free vs Descemet-on deep anterior lamellar keratoplasty

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Session Details

Session Title: Moderated Poster Session 03: Spotlight on Corneal Surgery

Session Date/Time: Monday 12/09/2016 | 14:00-15:00

Paper Time: 14:40

Venue: Poster Village: Pod 1

First Author: : H.Hasani IRAN

Co Author(s): :    M. Zare   S. Feizi   M. Rezaee   B. Hoseini   R. Shamsoddini Motlagh  

Abstract Details

Purpose:

To compare confocal features of grafts following deep anterior lamellar keratoplasty (DALK) using a donor without Descemet's membrane (DM) versus a full thickness donor with intact DM.

Setting:

Ophthalmology Department, Alborz University of Medical Sciences

Methods:

This retrospective comparative study examined 45 eyes from patients with keratoconus who underwent DALK using the big-bubble technique. The big-bubble technique yielded a bared DM in all keratoconic eyes. Twenty-seven eyes received tissue from a donor without DM (group 1), while 18 received tissue from a full thickness donor with an intact DM (group 2). A group of normal eyes (n=28, group 3) served as controls. Confocal microscopy was used to determine keratocyte density,explore the donor-recipient interface including clarity and reflectivity, evaluate endothelial cell density and morphology, as well as measure interface depth and central corneal thickness.

Results:

Mean follow-up duration was 20.2±8.6 months and 29.6±17.0 months in groups 1 and 2, respectively (P=0.13). Confocal scan demonstrated that the keratocyte profiles and distribution were more similar to normal corneas in group 2. Significantly more severe interface haziness was observed when donor DM was retained (mean interface reflectivity value of 102.7±22.1 versus 161.7±30.0 light reflectance units in groups1 and 2 respectively, P<0.001).

Conclusions:

Graft cellular profiles and healing response at the donor-recipient interface can be profoundly affected depending on whether donor DM is removed or retained.

Financial Disclosure:

NONE

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