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10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits

 

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MMP9 protein level in tear film as a possible diagnostic marker for keratoconus

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Session Details

Session Title: Presented Poster Session: Ocular Pathologies

Session Date/Time: Sunday 11/09/2016 | 15:00-16:30

Paper Time: 16:10

Venue: Poster Village: Pod 4

First Author: : A.Zilfyan ARMENIA

Co Author(s): :    E. Ghazaryan              

Abstract Details

Purpose:

The purpose of our study was evaluation of MMP 9 protein level in tear films of patients with keratoconus, and comparison with the data from normal cohort.

Setting:

All examinations were done at Shengavit medical center. Slit-lamp, autorefractor/ keratometer, corneal topographer and Pentacam were used for patients’ examinations.

Methods:

Sixty subjects with or without keratoconus diagnosis were included in this study. All participates were previously informed and gave their signed contest to the study. MMP 9 protein level was detected with rapid, in-office InflammaDry test. The test was performed in one eye of the participant prior to any eye drop instillation or ocular examination, and without anesthetic eye drops. The test was performed and interpreted by an ophthalmologist, who was blinded to the experimental groups. Statistical analyze was done by IBM SPSS 22.0. Pearson’s Chi-Squared test was used to examine the correlation between keratoconus diagnosis and positive test results.

Results:

All sixty subjects were Armenians. Thirty of them were diagnosed with keratoconus and composed examination group and the other thirty didn’t have keratoconus and were included in the control group. In the keratoconus group 27 patients had positive test results and 3 patients had negative results (90% and 10% respectively). In the control group only 4 subjects were positive (13.3%), while 26 subjects were negative for the test (86.7%). Statistical analyze showed significant correlation between the keratoconus and positive InflammaDry results with Chi-square value of 35.3 , df 1 and P value less than 0.001. Pearson’s correlation coefficient was 0.767.

Conclusions:

Recent studies showed the possible role of inflammation in keratoconus pathogenesis. We further wanted to check the levels of MMP 9 protein in tear films of patients with keratoconus and to examine the InflammaDry test reliability in detection of MMP9 protein not only in patients with dry eye disease, but also with keratoconus. Our results showed that MMP9 level is highly elevated in tears of patients with keratoconus. Pearson’s correlation coefficient of 0.767 showed strong positive relation between keratoconus diagnosis and positive test results, hence InflammaDry test can be useful tool in diagnosis of keratoconus.

Financial Disclosure:

NONE

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