Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Isopropyl alcohol-based excision biopsy of ocular surface squamous neoplasia (OSSN) and closing the big conjunctival defect with a small autograft by a newer technique

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Session Details

Session Title: Presented Poster Session: Ocular Pathologies

Session Date/Time: Sunday 11/09/2016 | 15:00-16:30

Paper Time: 15:50

Venue: Poster Village: Pod 4

First Author: : A.Mazhari INDIA

Co Author(s): :    P. Mahajan   R. Shukla   P. Chakarpani   R. Kairati     

Abstract Details


To assess the safety and clinical outcomes in patients over a period of 3 years who undergone excision biopsies of ocular surface squamous neoplasia (OSSN) and the big resultant conjunctival defects were closed with small autograft by a newer 'step ladder' pulling and suturing technique.


Cornea and refractive services, Indira Gandhi Eye Hospital and Research Centre, Lucknow, India


8 eyes with diffuse OSSN extending over five or more limbal clock hours or by extensive corneal spread were treated by isopropyl alcohol based excision with 3-4 mm clear conjunctival margins, cryotherapy of edges and closing of big conjunctival defects with small (4- 6 mm) autografts. The defects were pulled in a step ladder pattern to avoid restriction of eyeball movements postoperatively and secured with the autograft by 8-0 vicryl sutures. Two interrupted cycles of 0.04 % Mitomycin C eye drop were given. These cases were assessed for safety and efficacy of procedures during follow up.


The mean age at presentation of OSSN was 42 years. These cases were observed over a period of three years postoperatively and during the follow ups there were no recurrences of OSSN and its complications, and there were no restriction to eye movements.


Diffuse OSSN is sometime recalcitrant to initial treatment with chemotherapy alone and recurrences are also common. Combined approach of excision biopsy and cycles of chemotherapy appears to be safe approach for diffuse OSSN. Isopropyl alcohol based separation of OSSN mass from the cornea is easy because of loosening of corneal epithelium. The resultant big conjunctival defects can be closed effectively by a small autograft by 'step ladder' pulling of conjunctival margins and securing it with the autograft. AMG is the first choice for closing the big conjunctival gap but in few cases of limited resources, our technique is quite effective.

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