Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Explantation and replacement of an exchangeable optic in a new modular IOL system

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Session Details

Session Title: Presented Poster Session: Monofocal IOL

Session Date/Time: Sunday 11/09/2016 | 09:30-11:00

Paper Time: 10:50

Venue: Poster Village: Pod 4

First Author: : N.Mamalis USA

Co Author(s): :    L. Werner   J. Guan   J. Li   N. Reiter     

Abstract Details


To evaluate the stability and ease of explantation/exchange of a new modular intraocular lens (IOL) system consisting of a hydrophobic acrylic base unit and a hydrophobic acrylic optic in the rabbit model. A previous study demonstrated excellent biocompatibility and capsular bag stability with less capsular bag opacification with the modular IOL in comparison to a commercially available standard lens.


John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA


Five New Zealand white rabbits were utilized. Bilateral phacoemulsification was performed; one eye received the test IOL (ClarVista Harmoni Modular IOL System) and the other a commercially available hydrophobic acrylic IOL (Alcon AcrySof SA60AT). Slit lamp examinations were performed weekly during postoperative weeks 1 to 6. IOL exchange procedures were performed at weeks 2 and 6 using standard instruments. The rabbits were sacrificed at the end of the study (week 6), with all globes analyzed grossly using the Miyake-Apple technique and sectioned and processed for histopathologic evaluation.


The base component and the optic of the test IOL system remained stable and centered throughout the clinical follow up. Disengagement of the optic component from the base, as well as bisection of the optic in the anterior chamber followed by explantation/exchange of the optic of the test lens were safely and easily accomplished at 2 and 6 weeks postoperatively. Explantation of the control lens required significant posterior synechiolysis and capsular bag manipulation due to the position of the loops at the periphery of the bag, thus causing zonular stress. Although not the objective of this study, the test lens was associated with less capsular bag opacification.


Explantation/exchange of the Modular System Optic was found to be safer and easier than the explantation/exchange of the control IOL. The base component and optic remained stable and centered throughout the study. The modular IOL significantly reduces capsular bag opacification due to the long C loops, and separation of anterior and posterior capsules by square edged contact.

Financial Disclosure:

One or more of the authors research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented

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