Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Comparison of glaucoma probability score and Moorfields regression analysis to discriminate glaucomatous and healthy eyes

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Session Details

Session Title: Presented Poster Session: Glaucoma

Session Date/Time: Sunday 11/09/2016 | 15:00-16:30

Paper Time: 15:00

Venue: Poster Village: Pod 3

First Author: : C.Caglar TURKEY

Co Author(s): :    A. Gul   M. Batur   T. Yasar        

Abstract Details


To review and compare the sensitivity and specificity values of the Heidelberg Retinal Tomograph 3 (HRT-3) glaucoma probability score (GPS) and Moorfields Regression Analysis (MRA) for discriminating between healthy and glaucomatous eyes.


Yuzuncu Yil University, Faculty of Medicine, Ophthalmology Department, Glaucoma Unit.


A total of 258 eyes of 148 individuals (120 eyes of 75 glaucoma patients and 138 eyes of 73 healthy subjects) were enrolled in this prospective cross-sectional study. Confocal scanning laser ophthalmoscopy was performed with HRT. Performance of GPS and MRA were evaluated by considering borderline (BL) cases as within normal limits (WNL) or as outside normal limits (ONL). The glaucoma patients had an IOP of >21 , and repeatably detectable glaucomatous visual field defects with optic nerve damage. The normal control subjects had an IOP of <21 , normal optic disc appearance and a normal visual field.


There was no difference between glaucoma patients and normal subjects in terms of gender, disc area, and pachymetry (p>0.05). The GPS was higher, average visual field MD and PSD values were worse, and patients were older in glaucoma group (p=0.001). Sensitivity and specificity values were 72.5% and 93.8% respectively for MRA and 75.0% and 88.8% for GPS when BL cases considered as WNL, and when BL cases considered as ONL these values were 83.8% and 73.8% for MRA and 88.8% and 70.0% for GPS. There was no difference between sensitivity and specificity values of GPS and MRA for either situation (p>0.05). Sensitivity of GPS (76.2%) was higher than of MRA (61.9%) in initial glaucomatous eyes (p=0.317).


In general, the diagnostic performance of the contour line-independent GPS is similar to that of the MRA. However, GPS tended to have higher sensitivities and somewhat lower specificities. Clinicians should be aware of the strong size dependence of both GPS and MRA. These results suggest that in this population, MRA and GPS differentiate between glaucomatous and healthy eyes with good sensitivity and specificity.

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