Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance
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10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits

 

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Correlation between central stromal demarcation line depth and flattening of the cornea after corneal cross-linking comparing two different treatment protocols

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Session Details

Session Title: Presented Poster Session: Cross-linking

Session Date/Time: Sunday 11/09/2016 | 09:30-11:00

Paper Time: 10:10

Venue: Poster Village: Pod 3

First Author: : N.Pircher AUSTRIA

Co Author(s): :    J. Lammer   A. Gschliesser   R. Donner   S. Pieh   G. Schmidinger  

Abstract Details

Purpose:

A corneal stromal demarcation line (DL) induced by corneal cross-linking (CXL) has lately been suggested as a possible surrogate parameter for the flattening effect and success of the CXL-procedure. Aim of this study was to investigate the correlation between depth of the DL in the center of the cornea 1 month (mo) and reduction in maximal keratometry values (Kmax) 12mo after CXL treatment as well as comparing the effect in two different treatment protocols.

Setting:

Department of Ophthalmology and Optometry, Medical University of Vienna

Methods:

Treatment-naive subjects with keratoconus were treated either following the Standard Dresden Protocol (SDP, 30 minutes (min) Riboflavin + 20% Dextran [Peschke D] soaking, 30min irradiation UVX-1000, 3mW/cm2) or an Accelerated CXL Protocol (ACP, 10min HPMC [Vibex Rapid] soaking, 10min irradiation UVX-2000, 9mW/cm2). Depth of the DL was measured using Visante anterior segment OCT (Carl Zeiss Meditec Inc.) imaging 1mo post-operatively (OP). Kmax (preOP) and change in Kmax (preOP - 12mo postOP) were assessed using corneal topoghrapy (Pentacam HR tomography, Oculus GmBH).

Results:

50 eyes were treated according to the SDP and 36 eyes to the ACP. PreOP mean±SD Kmax was 57.26±6.97 D in the SDP group and 56.82±6.36 D in the ACP group (p=0.10). A DL was observed in all eyes of both groups [(326.57±76.64 µm SDP and 168.74±73.15 ACP (p<0.001)]. Mean change in Kmax was -1.32±2.04 D after 12mo in the SDP group (p<0.001) and -0.77±2.36 D in the ACP group (p=0.75). No statistically significant correlation between depth of the DL after 1mo and change in Kmax after 12mo was found in either of the groups (Pearson r: -0.09 and -0.02)

Conclusions:

Different CXL treatment protocols seem to induce different depths of the DL. Even though eyes that were treated following the Standard Dresden Protocol showed a deeper DL and a significant change in Kmax at 12 mo, the interpretation of the stromal depth of the DL as a surrogate parameter for the effect of the procedure may be doubted.

Financial Disclosure:

NONE

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