Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Twenty-four months clinical results of accelerated transepithelial corneal cross-linking for progressive keratoconus

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Session Details

Session Title: Presented Poster Session: Cross-linking

Session Date/Time: Sunday 11/09/2016 | 09:30-11:00

Paper Time: 10:00

Venue: Poster Village: Pod 3

First Author: : W.Aixinjueluo JAPAN

Co Author(s): :    T. Usui   T. Miyai   T. Toyono   S. Yamagami     

Abstract Details


To evaluate the clinical results of accelerated transepithelial corneal crosslinking (CXL) in patients with progressive keratoconus.


This is an independent clinical study of Department of Ophthalmology, Tokyo University Hospital under approval of the Institutional Review Board (IRB) of The University of Tokyo Hospital. Patients were recruited from the outpatients of Department of Ophthalmology, The University of Tokyo Hospital.


All patients were followed up clinically on the first day, at 1 week, 2 weeks, 1 month, 3 months, 6 months, 12 months and 24 months postoperatively. UVA treatment was performed with the Avedro KXL at 30mW/cm(2) for 3 minutes. Preoperative and postoperative examinations included uncorrected visual acuities (UCVA), best corrected visual acuities (BCVA), average keratometry (AveK), maximum keratometry (Kmax), central corneal thickness (CCT), thinnest corneal thickness, endothelial cell density (ECD), intraocular pressure and non-mydriatic indirect fundus examination. Patients were also asked to report any pain or discomfort during the procedure.


The study included 21 eyes of 15 patients treated by accelerated transepithelial CXL with mean age of 26 years. BCVA showed significant improvement while UCVA showed no remarkable change. There was significant decrease in Kmax and AveK at the end of 24 months. There was significant decrease in thinnest corneal thickness but no decrease in CCT. ECD showed no significant change. There were no postoperative corneal haze, corneal edema, sterile infiltrates, infection and significant endothelial damage throughout the follow-up period. The intraocular pressure and fundus showed no significant change. Pain or foreign-body sensation following transepithelial CXL appeared especially in the first 2 days, but no more than 1 week in all cases.


In patients with progressive keratoconus, accelerated transepithelial CXL showed improvement of BCVA, Kmax and AveK reduced postoperative pain.

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