Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance
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10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits

 

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Corneal thickness measurement in patients with keratoconus after accelerated cross-linking: comparison between Scheimpflug imaging system and anterior segment spectral-domain optical coherence tomography

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Session Details

Session Title: Presented Poster Session: Cross-linking

Session Date/Time: Sunday 11/09/2016 | 09:30-11:00

Paper Time: 09:50

Venue: Poster Village: Pod 3

First Author: : J.Woo SINGAPORE

Co Author(s): :    H. Htoon   L. Lim           

Abstract Details

Purpose:

To compare the central and minimum corneal thickness measurement using the Scheimpflug imaging system and anterior segment spectral-domain optical coherence tomography in patients with keratoconus after accelerated crosslinking.

Setting:

Singapore National Eye Centre, Singapore

Methods:

51 eyes with keratoconus were included. They underwent accelerated crosslinking with the KXL system (Avedro Inc., Waltham, MS, USA) using dextran-free riboflavin 0.1% solution (VibeXRapid, Avedro Inc.).The central and minimum corneal thickness were measured using Pentacam HR system (Oculus Optikgerate GmbH, Wetzlar, Germany) and Optovue (RTVue-100, Optovue Inc., Fremont, CA) at baseline, 1 month, 3 months, 6 months and 1 year post-procedure. The change in corneal thickness on follow up was analysed using a linear mixed model. Measurements from the 2 devices were correlated with the Intraclass Correlation Coefficient (ICC). Inter-modality agreement was assessed using Bland-Altman comparison analysis.

Results:

Both central (473.2 µm +/-33.0; mean change -22.7 µm +/-26.2; P<0.001) and minimal corneal thickness (444.8 µm +/-36.7; mean change -17.5 µm +/-26.5; P<0.001) were reduced at 1 month but recovered towards baseline thickness at 1 year, as measured by the Pentacam. However, both measurements remained stable on the Optovue between baseline and 6 months before increasing at 1 year (central 484.1 µm +/-29.3, mean change 7.7 µm +/-10.3; minimal 450.8 µm +/-31.5, mean change 4.4 µm +/-12.2). Both modalities were highly correlated for central (ICC 0.823 to 0.943) and minimal corneal thickness (ICC 0.766 to 0.961). The mean bias was greatest at baseline (central 22.4 µm, CI 18.2 to 26.7; minimal 25.1 µm, CI20.9 to 29.4)

Conclusions:

The trend of initial corneal thinning followed by gradual recovery to baseline thickness after crosslinking was observed in Pentacam, but not Optovue measurements. Throughout the course of follow up, the degree of correlation between the 2 modalities remained high. Pentacam consistently overestimated corneal thickness compared to Optovue.

Financial Disclosure:

NONE

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