Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance
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10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits

 

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Evaluation of posterior capsular opacification using new automated detector opacification software (ADOS)

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Session Details

Session Title: Presented Poster Session: PCO

Session Date/Time: Sunday 11/09/2016 | 09:30-11:00

Paper Time: 09:50

Venue: Poster Village: Pod 1

First Author: : C.Mastromonaco CANADA

Co Author(s): :    M. Balazsi   P. Zoroquiain   P. Logan   S. Maloney   M. Burnier  

Abstract Details

Purpose:

Posterior capsular opacification(PCO) is the leading complication following cataract surgery. However, PCO grading methods vary between studies involving eyebank eyes and animal models, and no unified scoring is available to allow global analysis of PCO. Furthermore, most grading relies on subjective scoring. Therefore, software that reduces subjectivity and enhance reproducibility is needed. The aim of the study was to evaluate the reproducibility and objectivity of a novel automated custom-designed PCO detection software.

Setting:

MUHC- RI, McGill University, Montreal, Quebec, Canada

Methods:

Twenty-five fixed eyes with intraocular lenses (IOLs) were sectioned to obtain a Miyake Apple view(MAV) image.The capsular bag (CB) with the in-situ IOL was removed and imaged using the Olympus DSX100 Stereoscope. Peripheral (Soemmering’s ring area[SRA] and Soemmering’s ring intensity[SRI]) and central PCO were graded by two evaluators using a standard scale; 0=clear;1=mild;2=mild-moderate;3=more marked;4=severe. A custom image analyzer (Medical Parachute ADOS) was developed to detect PCO on the CB images, and correlated with subjective scoring.

Results:

Agreement between evaluators was analyzed using the weighted kappa test for SRA,SRI and central PCO scores in both MAV and CB images.Spearman’s and Pearson’s correlation was performed between the evaluators scores for MAV and CB images. Subjective grading had slight to moderate agreement for SRA, SRI and central PCO between graders on MAV(k=0.302, 0.489, 0.202 respectively) and CB view(k=0.457, 0.585, 0.564, respectively). Correlation between MAV and CB images on SRA, SRI and central was high for peripheral PCO and low for central PCO in both grader 1(r=0.809, 0.816, 0.466 respectively) and grader 2(r=0.766, 0.876, 0.130 respectively). Software grading was 100% reproducible(k=1.0), and SRA, SRI and central evaluation correlated strongly to moderately with standard subjective grading(r=0.41, 0.73, 0.46 respectively).

Conclusions:

The ADOS correlates with previous scoring methods and is a reliable and reproducible system that allows the comparison between worldwide studies without variability. Moreover, the CB view as opposed to the MAV, allows visualization of the capsular bag directly and avoids the overlapping of other altered structures (vitreous, cornea) that may interfere with proper central PCO quantification.


Financial Disclosure:

One or more of the Authors gains financially from product or procedure presented

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