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10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits

 

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The biomechanical properties of rabbit cornea using inflation test at different corneal cross-linking irradiances

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Session Details

Session Title: Presented Poster Session: Corneal Biomechanics

Session Date/Time: Saturday 10/09/2016 | 15:00-16:30

Paper Time: 15:30

Venue: Poster Village: Pod 4

First Author: : S.Chen CHINA

Co Author(s): :    S. Chen              

Abstract Details

Purpose:

The Bunsen-Roscoe law states that a photochemical reaction should stay constant if the delivered total energy is kept constant. In order to evaluate the Bunsen-Roscoe law in corneal collagen cross-linking,we investigate the corneal biomechamical properties using inflation test at different corneal cross-linking irradiances,while the delivered total energy is kept constant.

Setting:

The Affiliated Eye Hospital, Wenzhou Medical University.

Methods:

Fifty-six rabbits were randomly divided into 7 groups . All the left eys served as treat group,and all right eyes as normal group.6 groups were exposed to riboflavin 0.22% and UV-A(370nm) irradiationiation of equal total energy (3 mW/cm 2 for 30 minutes, 9 mW/cm 2 for 10 minutes, 18 mW/cm 2 for 5minutes,30mw/cm2 for 3 minutes, 45 mW/cm 2 for 2minutes, 90 mW/cm 2 for 1 minute). The control eyes were exposed to riboflavin 0.22% without irradiation. All eyes were prepared for inflation test 1 week postoperatively. And inverse modeling technology was used to get tangent elastic modulus.

Results:

The biomechanical parameters of CXL decreased when using high irradiation/short irradiation time CXL. The tangent elastic modulus at different stress (0.002 Mpa,0.004 Mpa,0.006Mpa)showed significant increases between 3 mW/cm 2 and the normal group (91.46%~109.1% ), 9 mW/cm 2 and the normal group (73.6%~81.90%). There was no difference between 18 mW/cm2 and the normal group (P>0.05) , 30 mW/cm2 and the normal group (P>0.05),45 mW/cm2 and the normal group (P>0.05),90 mW/cm2 and the normal group (P>0.05).

Conclusions:

The biomechamical properties of rabbit cornea underwent corneal collagen cross-linking decreased with increasing irradiance using inflation after a week. Both experimental data and stress-strain curves are valuable for understanding corneal biomechanics after CXL. Additional study is needed to determine why the biomechanical stiffness decreased with increasing irradiance, and Whether it is relevant to the oxygen state.

Financial Disclosure:

NONE

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