Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Clinical outcomes of re-do Descemet’s membrane endothelial keratoplasties (DMEK) following failed DMEK performed at a multi-surgeon ophthalmic teaching hospital: a retrospective case series

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Session Details

Session Title: Presented Poster Session: Surgical Cornea

Session Date/Time: Saturday 10/09/2016 | 15:00-16:30

Paper Time: 15:30

Venue: Poster Village: Pod 3

First Author: : K.Muthusamy UK

Co Author(s): :    H. On   R. Stewart   S. Fung   M. Wilkins   V. Maurino  

Abstract Details


DMEK has been introduced as an alternative to Descemet’s stripping endothelial keratoplasty (DSEK) and Descemet’s stripping automated endothelial keratoplasty (DSAEK) as a surgical treatment of patients with corneal endothelial dysfunction. This case series evaluates the outcomes of 14 patients who underwent secondary Descemet membrane endothelial keratoplasty (DMEK) to manage graft failure after primary DMEK performed by different surgeons in a large multi-surgeon ophthalmic teaching hospital.


Moorfields Eye Hospital, London, United Kingdom


This was a retrospective observation study investigating secondary Descemet membrane endothelial keratoplasty (DMEK) to manage graft failure after primary DMEK procedures performed at Moorfields Eye Hospital between July 2013 to December 2015. All patients who had DMEK procedures during this period had pre-operative data and post-operative data at 3-months and 6-months collected from a review of medical records. Data collected included patient demographics, ocular co-morbidities, pre- and post- operative visual acuities, central corneal thickness, corneal endothelial cell count, and reasons for graft failure. Donor graft characteristics were also recorded.


14 secondary DMEK procedures were performed between July 2013 and December 2015. Median age of patients was 66.0 years. 92% of cases were performed by a consultant surgeon. Average time to second surgery was 8.6 weeks. Of the 14 cases performed, 3 patients underwent re-bubbling for graft detachment and 2 patients developed primary graft failure. Post-operative follow-up data was available at 3-months for 13 patients and at 6-months for 9 patients. 12 patients who underwent successful secondary DMEK surgery had significantly better visual acuity than preoperative levels (p<0.05) with 7 patients achieving BCVA of 6/9 or better.


Secondary DMEK surgery is successful management option for the treatment of failed primary DMEK grafts. Patients who undergo secondary DMEK surgery are potentially able to achieve the same level of visual rehabilitation as successful primary DMEK.

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