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Topical timolol may inhibit corneal neovascularization in rabbits

Poster Details

First Author: M.Ghomi IRAN

Co Author(s): A. Kasiri   M. Feghhi   F. Farrahi   M. Mirdehghan   H. Hedayati        

Abstract Details


Timolol is a non-selective antagonist beta-adrenergic which is similar to propranolol. The mechanism of action on the regression of neovascularization is unknown, but it appears that it acts through the vascular endothelial growth factor (VEGF), vasoconstriction and induction of apoptosis of vascular endothelial cells.


This is an experimental study performed at Ahvaz University of Medical Sciences, Iran.


Twenty male rabbits selected weighing between 1500 to 1900 grams. Following induction of neovascularization of eyes two different groups were investigated. The first group (timolol twice daily) and the second group (saline group twice daily).


Seven days later the mean percentage area of neovascularization compared to baseline in the timolol group was 4.63 ± 4.61% however in saline group was 58.39± 6.31 percent (control group). After 2 weeks the mean percent area of neovascularization compared to baseline in the timolol group was 0.85± 1.33% wherase 1.73 ± 2.06 percent in saline. After a week of treatment, neovascularization area in the timolol group was significantly lower than the control group (p <0.001).


Application of timolol increases the recovery rate of corneal neovascularization. After the first week, neovascularization in timolol group was significantly lesser than the control group.

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