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Characteristics of corneal endothelial cells in bilateral keratoconus cases with unilateral corneal Vogt’s striae

Poster Details


First Author: S.Rajabi IRAN

Co Author(s): F. Askarizadeh   H. Ostadi-Moghaddam   M. Sedaghat   F. Narooie-Noori   T. Rakhshandadi        

Abstract Details

Purpose:

The aim of this study was to compare corneal endothelial cell morphology and characteristics in bilateral keratoconus (KCN) cases with unilateral Vogt’s striae.

Setting:

This prospective contralateral eye study conducted from February 2017 to Juan 2017 at Sedaghat Eye Clinic, Mashhad, Iran. All participants were residents of Mashhad with the same ethnicity.

Methods:

In this prospective contralateral eye study, corneal endothelial cell parameters were evaluated in bilateral KCN patients whose corneas had slit lamp biomicroscopic evidence of unilateral Vogt’s striae using the Topcon SP2000P specular microscope (Topcon, Tokyo, Japan). All the cases underwent a comprehensive ophthalmic examination, including uncorrected and corrected distance visual acuity, refraction, slit lamp biomicroscopy, and Scheimpflug-based tomography. The KCN cases that were enrolled in this study had a reliable diagnosis of bilateral clinical KCN with unilateral Vogt`s striae based on slit-lamp signs, as well as corneal topographic/tomographic maps.

Results:

Fifty patients aged 20 to 38 years were recruited in this study. Our results revealed significant differences in corrected and uncorrected distance visual acuity, refractive error components, central corneal thickness, and maximum keratometry between KCN eyes with and without Vogt’s striae (all P<0.05) except for J45 (P=0.131). In the current study, there were no significant differences in corneal endothelial cell parameters including endothelial cell density (ECD), hexagonal cell ratio (HEX), and coefficient of variance of cell size (CV) between the two groups [(P=0.618), (P=0.658), and (P=0.467), respectively)]. Also, among KCN groups with and without Vogt’s striae, ECD didn’t correlate with anterior chamber depth [(P=0.564, r=0.09), (P=0.219, r=-0.18), respectively], maximum keratometry [(P=0.215, r=0.18), (P=0.898, r=0.02), respectively] and central corneal thickness [(P=0.989, r=-0.02), (P=0.643, r=-0.07), respectively].

Conclusions:

Our study showed no significant differences in ECD, HEX, and CV between KCN eyes with and without Vogt’s striae. Despite clinical and tomographic results, it seems that Vogt`s striae cannot cause deterioration in the corneal endothelial morphology.

Financial Disclosure:

None

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