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Corneal endothelial cells changes after photorefractive keratectomy with or without mitomycin C

Poster Details

First Author: M.Abdel Hamid Mohammed EGYPT

Co Author(s):                     

Abstract Details


To compare differences in the endothelial cells before and after photorefractive keratectomy (PRK) for myopia with or without mitomycin C (MMC) application.


Suez Canal University Hospital , Ismailia , Egypt


In a prospective randomized clinical trial, fifty myopic patients with 100 eyes who prepared for PRK in suez city ,Egypt. Patients were treated with PRK by zeiss MEL90 . MMC was applied after PRK 15 s for each eye for first 25 patients in 50 eyes only . The manifest refraction, visual acuity, MMC treatment length, corneal pachymetry and specular microscopy were evaluated preoperatively and at 1 and 3 months postoperatively.


A total of 50 cases (100 eyes, 68.75% female) were treated, with a mean age of 26.70 ± 4.89 years (range, 18-34 years). Postoperative cell density, cell size and polymegathism did not significantly change. On the other hand, standard deviation (SD) of cell size (P = 0.008), pleomorphism (P = 0.003) and coefficient of variation (CV) (P = 0.016) were significantly increased. None of these parameters was related to the length of MMC application but was more obvious in MMC group more than non MMC group. Corneal thickness decreased significantly after the operation but it increased 3 months postoperatively compared with the first month (P < 0.001).


PRK for myopia can affect the endothelial cells and this effect increased after MMC application , but in early follow-ups, it does not affect the cell density or size. Cell size was changed but it was obvious not in mean cell size, but in SD and CV. MMC time below the 30 s was not significant on endothelial cell changes.

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