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The role of corneal confocal microscopy in multiple sclerosis

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Session Details

Session Title: Moderated Poster Session: Miscellaneous
Session Date/Time: Saturday 10/02/2018 | 14:00-15:00
Paper Time: 14:24
Venue: Poster Area

First Author: P.Mellace ITALY
Co Author(s): S. Fazio  F. Martino  E. Polito           

Abstract Details


To analyze the effect of Multiple Sclerosis on corneal nerve fibers in the subbasal nerve plexus using in vivo confocal microscopy (IVCM).


Ophthalmology Unit, Department of Medical, Surgical and Neurosciences. Siena University, Italy


In this prospective study the corneal nerve fiber density was measured in 24 MS patients (mean age ± SD [years]: 42.5 ± 16.3), and 25 healthy controls (HC) (41.7 ± 15.4), using a Heidelberg Retinal Tomograph with Rostock Cornea Module. Cirrus optical coherence tomography (OCT) was carried out in each patient.


A significant reduction in corneal nerve fiber density was observed in MS patients (14348.3 ± 1672.72 µm/mm^2) compared to controls (17850.26 ± 1874.9 µm/mm^2). Total corneal nerve fiber density had been high correlation with temporal peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thickness.


Corneal nerve fiber density may be considered as a potential surrogate marker for disease diagnosis, severity and progression in MS and should be further investigated.

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